Cardiothoracic & vascular anesthesia
High‐sensitive troponinT, interleukin‐8, and interleukin‐6 link with post‐surgery risk in infant heart surgery
Authors' conclusion
The peak biomarker concentrations and CPB-time strongly predicted AKI2-3, with IL-6 and IL-8 emerging as strongest predictors.
Study context
- Population
- Infants undergoing open heart surgery with cardiopulmonary bypass (CPB)
- Participants
- 70 infants
- Primary endpoint
- Association of peak hs-cTnT, IL-6 and IL-8 with postoperative acute kidney injury (AKI), ventilatory support time and need of vasoactive drugs
Methodological detailsexploratory, double-blinded, Entire study population examined without considering the study drugs
- Exploratory
- Double-blinded
- Entire study population examined without considering the study drugs
Primary result
As reported in the abstract
AKI2-3
OR for AKI2-3, IL-6 > 293 pg/mL
23.4
95% CI 5.3;104.0
OR for AKI2-3, IL-8 > 100 pg/mL
11.5
3.0;44.2
OR for AKI2-3, hs-cTnT >5597 pg/mL
6.1
1.5; 24.5
Further findings
Timing of peak biomarker concentration · 2 h post-CPB
- Peak IL-8 at 2 h post-CPB
- 96%
- Peak hs-cTnT at 2 h post-CPB
- 79%
- Peak IL-6 at 2 h post-CPB
- 63%
Ventilatory support >24 h and vasoactive drugs at 24 h post-CPB
- In more than two third of patients with the highest peak IL-8, IL-6 and hs-cTnT; in less than one third of patients with the lowest peak IL-8 and hs-cTnT
Original publication
High‐sensitive troponinT, interleukin‐8, and interleukin‐6 link with post‐surgery risk in infant heart surgery. Acta Anaesthesiol Scand. Published 26 March 2024. doi:10.
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