Hemodynamics, fluids & transfusion
High vasopressor doses are associated with decreased tissue oxygenation in critically ill patients: a secondary analysis of a prospective cohort
Authors' conclusion
High vasopressor requirements are associated with impaired microcirculatory oxygenation of the hand regardless of systemic blood pressure.
Study context
- Population
- Surgical ICU patients; Hyperspectral imaging (HSI) of the hand on the day of admission
- Participants
- 502 patients
- Comparison
- Vasopressor load and tissue oxygenation by hyperspectral imaging
- Primary endpoint
- Association between NEE and StO₂
- Follow-up
- Day of admission
Primary result
As reported in the abstract
StO₂ vs NEE (multivariable linear regression)
- Higher Norepinephrine Equivalent (NEE) independently associated with lower StO₂ (B)
- - 0.0931
- Standardised β
- −0.193
- P
- p = 0.001
Further findings
Highest NEE quartile (> 0.28) · 30 days
- 30-day mortality
- 41.8%
- Lowest StO₂
Mediation of vasopressor load and arterial lactate
- StO₂ partially mediated the relationship
StO₂ change after shock reversal (NEE ≤ 0.05, lactate < 2mmol/l, MAP ≥ 65mmHg for ≥24 h)
- StO₂ improvement
- + 5.8%
- P
- P < 0.001
Original publication
High vasopressor doses are associated with decreased tissue oxygenation in critically ill patients: a secondary analysis of a prospective cohort. Crit Care. Published 29 May 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →