Cardiac arrest & resuscitation
Higher versus lower mean arterial blood pressure after cardiac arrest and resuscitation (mean arterial pressure (MAP)‐CARE): A protocol for a randomized clinical trial
An erratum to this article was published (Acta Anaesthesiol Scand, Mar 2026 ↗)
Study context
- Population
- Adults with sustained ROSC who are comatose after OHCAplanned sample size
- Participants
- 3,500 adults
- Planned comparison
- Higher vs lower MAP target after resuscitation
- Primary endpoint
- Mortality
- Follow-up
- 6 months
Methodological details2 x 2 x 2 factorial (STEPCARE), international, multicentre, parallel-group, investigator-initiated, superiority, Neurological prognostication per ERC and ESICM guidelines by a physician blinded to allocation, Sample size gives 90% power, alpha 0.05, to detect 5.6 absolute risk reduction in 6-month mortality, assuming 60% control mortality, Secondary outcomes: poor functional outcome and patient-reported overall health at 6 months; predefined severe adverse events
- 2 x 2 x 2 factorial (STEPCARE)
- International
- Multicentre
- Parallel-group
- Investigator-initiated
- Superiority
- Neurological prognostication per ERC and ESICM guidelines by a physician blinded to allocation
- Sample size gives 90% power, alpha 0.05, to detect 5.6 absolute risk reduction in 6-month mortality, assuming 60% control mortality
- Secondary outcomes: poor functional outcome and patient-reported overall health at 6 months; predefined severe adverse events
No results yet. This paper sets out the design of a trial; its results are to come.
Original publication
Higher versus lower mean arterial blood pressure after cardiac arrest and resuscitation (MAP‐CARE): A protocol for a randomized clinical trial. Acta Anaesthesiol Scand. Published 20 May 2025. doi:10.
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