Respiratory failure & ventilation
Higher versus lower oxygenation targets in adult intensive care unit (ICU) patients: A rapid practice guideline
Methodological detailsGRADE approach, Evidence-to-Decision framework, Panel of 27 international panelists, Evidence base: updated systematic review and meta-analysis of 17 randomized clinical trials with 10,248 participants, Little to no difference between higher vs lower oxygenation targets for all outcomes with available data, incl. all-cause mortality, serious adverse events, stroke, functional outcomes, cognition, health-related quality of life (very low certainty of evidence)
- GRADE approach
- Evidence-to-Decision framework
- Panel of 27 international panelists
- Evidence base: updated systematic review and meta-analysis of 17 randomized clinical trials with 10,248 participants
- Little to no difference between higher vs lower oxygenation targets for all outcomes with available data, incl. all-cause mortality, serious adverse events, stroke, functional outcomes, cognition, health-related quality of life (very low certainty of evidence)
Recommendations
As issued by the authors
- conditional recommendation, very low certainty of evidence
We suggest against the routine use of higher oxygenation targets in adult ICU patients. Remark: an oxygenation target of SpO2 88%-92% or PaO2 8 kPa/60 mmHg is relevant and safe for most adult ICU patients.
Original publication
Higher versus lower oxygenation targets in adult ICU patients: A rapid practice guideline. Acta Anaesthesiol Scand. Published 23 December 2023. doi:10.
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