Hospital-acquired bloodstream infections in critically ill cirrhotic patients: a post-hoc analysis of the EUROBACT-2 international cohort study
Authors' conclusion
Critically ill cirrhotic patients with hospital-acquired bloodstream infections exhibit distinct epidemiology, with more Gram-positive infections and particularly Enterococcus faecium.
Study context
- Population
- Critically ill intensive care unit (ICU) patients with hospital-acquired bloodstream infections
- Participants
- 1,059 patients · 101 centres
- Comparison
- Cirrhotic vs Non-cirrhotic
- Cirrhoticn = 160
- Primary endpoint
- Epidemiological differences in hospital-acquired bloodstream infections: infection sources, microorganisms and mortality
Methodological detailspost-hoc analysis, multicentre, multivariable mixed logistic regression, multivariable frailty Cox model
- Post-hoc analysis
- Multicentre
- Multivariable mixed logistic regression
- Multivariable frailty Cox model
Primary result
As reported in the abstract
E. faecium hospital-acquired bloodstream infection
P < 0.01
- Cirrhosis associated with higher E. faecium bloodstream infection risk after adjustment for confounders (multivariable mixed logistic regression): OR
- 2.5 (95% CI 1.3-4.5, p < 0.01)
Original publication
Hospital-acquired bloodstream infections in critically ill cirrhotic patients: a post-hoc analysis of the EUROBACT-2 international cohort study. Ann Intensive Care. Published 2 May 2024. doi:10.
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