Sepsis & infection

Hospital Strain During the COVID-19 Pandemic and Outcomes in Older Racial and Ethnic Minority Adults

JAMA Netw OpenPublished Cross-sectional study

Authors' conclusion

In this cross-sectional study, older adults hospitalized with sepsis were more likely to die or experience major morbidity as the hospital COVID-19 burden increased. These increases in adverse outcomes were greater in magnitude among members of minority populations than for White individuals.

Study context

Population
Older adults hospitalized with sepsis, Medicare claims, January 1, 2016–December 31, 2021hospitalizations for sepsis
Participants
5,899,869 adults
Exposure
Hospital weekly COVID-19 burden >40% vs before the pandemic, by race and ethnicity (Asian, Black, Hispanic vs White)
  • Asiann = 177,864
  • Blackn = 664,648
  • Hispanicn = 522,964
  • Whiten = 4,534,393reference
Outcome
Composite of:
  • All-cause 30-day mortality
  • Major morbidity
Follow-up
30 days
Methodological detailsmultivariable regression, Medicare claims data
  • Multivariable regression
  • Medicare claims data

Main finding

As reported in the abstract

Death or major morbidity when hospital weekly COVID-19 burden >40%
Adjusted odds ratio (95% CI)P value
White (COVID-19 burden >40%) vs White (before the pandemic)risk increased nearly 2-fold
1.90(1.80–2.00)
P < 0.001
Asian vs White44% higher risk
1.44(1.28–1.61)
P < 0.001
Black vs White21% higher risk
1.21(1.11–1.33)
P < 0.001
Hispanic vs White45% higher risk
1.45(1.32–1.59)
P < 0.001

Observational data: associations, not effects.

Original publication

Hospital Strain During the COVID-19 Pandemic and Outcomes in Older Racial and Ethnic Minority Adults. JAMA Netw Open. Published 1 October 2024. doi:10.1001/jamanetworkopen.2024.38563

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