Cardiothoracic & vascular anesthesia
Hypoperfusion and cardiac surgery-associated major adverse kidney events: a single-center retrospective cohort study
Authors' conclusion
Low intraoperative PPI is independently associated with an increased risk of MAKE30, CSA-AKI, and 30-day mortality following cardiac surgery with CPB.
Study context
- Population
- Adults undergoing cardiac surgery with cardiopulmonary bypass (CPB)analysed
- Participants
- 446 adults
- Exposure
- Time spent with low intraoperative peripheral perfusion index
- Outcome
- Major adverse kidney events (MAKE30)
Methodological detailssingle-center, multivariable logistic regression
- Single-center
- Multivariable logistic regression
Main finding
As reported in the abstract
MAKE30
Odds ratio (95% CI)P value
Every 15 min with PPI < 0.5
1.49(1.27–1.76)
P < 0.001Every 15 min with PPI <1.5
1.18(1.08–1.28)
P < 0.001Each row per its own increment, as printed
Observational data: associations, not effects.
Further findings
Cardiac surgery-associated acute kidney injury (CSA-AKI) and mortality
- Time with peripheral perfusion index (PPI) below 0.5 and 1.5 significantly associated with CSA-AKI and mortality
Sensitivity analyses (post-CPB periods, LASSO-based variable selection)
- Associations robust
Original publication
Hypoperfusion and cardiac surgery-associated major adverse kidney events: a single-center retrospective cohort study. Anaesth Crit Care Pain Med. Published 26 February 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →