Cardiothoracic & vascular anesthesia
The prognostic value of postoperative cardiac troponin I and T for major adverse cardiac events after coronary artery bypass grafting: a systematic review
Authors' conclusion
Postoperative cardiac troponin I and T biomarkers are associated with postoperative MACE after CABG. The current evidence on the predictive value for postoperative MACE is insufficient to use troponin I and T for risk stratification.
Study context
- Population
- Patients after coronary artery bypass graft (CABG) surgery10 studies
- Participants
- 1,956 vs 5,615
- Comparison
- Postoperative cardiac troponin I and T as prognostic markers for major adverse cardiac events (MACE)
- Troponin In = 1,956
- Troponin Tn = 5,615
- Outcome
- MACE:
- MI
- Coronary artery revascularisation
- Cardiac death
- Non-fatal cardiac arrest
- HF
Methodological detailsRisk of bias moderate to high across domains (Quality in Prognostic Studies tool)
- Risk of bias moderate to high across domains (Quality in Prognostic Studies tool)
Pooled result
As reported in the abstract
Association of increased postoperative troponin with MACE
| Group | HR range (n=2 studies) | OR range (n=5 studies) |
|---|---|---|
| Troponin I | 1.6-11.1 | |
| Troponin T | 0.9-67.9 |
HR range (n=2 studies)
Troponin I1.6-11.1
Troponin T— not stated in the abstract
OR range (n=5 studies)
Troponin I— not stated in the abstract
Troponin T0.9-67.9
Further pooled results
| Outcome | Troponin I | Troponin T |
|---|---|---|
| Discriminative performance (c-statistics) | ||
| C-statistics range (n=3 studies) | 0.60-0.81 | 0.72-0.77 |
| Calibration | ||
| Hosmer-Lemeshow P (in-hospital MACE, n=1 study) | — not stated in the abstract | P=0.20 |
— not stated in the abstract
Discriminative performance (c-statistics)
- Moderate to good for troponin I; moderate for troponin T
Calibration
- No studies reported calibration for troponin I; good calibration for troponin T
Original publication
The prognostic value of postoperative cardiac troponin I and T for major adverse cardiac events after coronary artery bypass grafting: a systematic review. BJA Open. Published 8 September 2025. doi:10.
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