Hypotension after general anaesthesia induction using remimazolam or propofol in geriatric patients undergoing sevoflurane anaesthesia with remifentanil: a single-centre, double-blind, randomised controlled trial
Authors' conclusion
Compared with propofol, remimazolam did not reduce the incidence of hypotension after general anaesthesia induction in patients aged ≥80 yr.
Study context
- Population
- Patients aged ≥80 yr receiving GA for scheduled surgery87 analysed
- Participants
- 90 patients
- Comparison
- Remimazolam vs Propofol
- Remimazolamn = 43
- Propofoln = 44reference
- Primary endpoint
- Incidence of hypotension after GA induction (noninvasive MAP <65 mm Hg, measured every minute)
- Follow-up
- From initiation of drug administration to 3 min after tracheal intubation
Methodological detailssingle-centre, double-blind, stratified by preoperative ward hypertension
- Single-centre
- Double-blind
- Stratified by preoperative ward hypertension
Primary result
As reported in the abstract
Incidence of hypotension after GA induction
- No statistically significant difference between groups
- 0.96 (aOR 0.96; 95% CI 0.37-2.46; P=0.93)
Further findings
Primary outcome by subgroup (preoperative ward hypertension, clinical frailty scale, Charlson Comorbidity Index, age)
- No significant differences between groups
Original publication
Hypotension after general anaesthesia induction using remimazolam or propofol in geriatric patients undergoing sevoflurane anaesthesia with remifentanil: a single-centre, double-blind, randomised controlled trial. Br J Anaesth. Published 22 May 2024. doi:10.
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