Respiratory failure & ventilation
Increased Driving Pressure During Assisted Ventilation for Hypoxemic Respiratory Failure Is Associated with Lower ICU Survival: The ICEBERG Study
An erratum to this article was published (Am J Respir Crit Care Med, 1 Jun 2026 ↗)
Authors' conclusion
During assisted ventilation, ΔP and normalized compliance are associated with ICU outcome, despite some overlap.
Study context
- Population
- Patients with acute hypoxemic respiratory failure on assisted ventilation, enrolled within 48 hours of triggering the ventilator
- Participants
- 298 patients · 16 centres
- Exposure
- ICU nonsurvivors vs survivors
- Outcome
- Quasi-static ΔP
- Follow-up
- First 3 days of assisted ventilation
Methodological detailsmulticentre
- Multicentre
Main finding
As reported in the abstract
Nonsurvivors
13
median · IQR 11–14 · cm H2O
Survivors
11
median · IQR 9–13 · cm H2O
P < 0.001
Observational data: associations, not effects.
Further findings
Compliance normalised to predicted body weight · first 3 days of assisted ventilation
P < 0.001
Median, cm H2O
| Outcome | Nonsurvivors | Survivors | P value |
|---|---|---|---|
| Transpulmonary dynamic ΔP · first 3 days of assisted ventilation | 19 (IQR 16–23) | 16 (IQR 13–18) | P < 0.001 |
Vt, peak airway pressure, PEEP, inspiratory effort · first 3 days of assisted ventilation
- Did not differ between survivors and nonsurvivors
Static ΔP over study days
- Significantly diverged between survivors and nonsurvivors
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
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