Identifying a unique signature of sepsis in patients with pre-existing cirrhosis
Authors' conclusion
We identified associations between pre-existing cirrhosis and endothelial injury, AKI, and mortality in sepsis.
Study context
- Population
- Critically ill patients presenting with sepsis, single centre
- Participants
- 2,962 patients
- Exposure
- Pre-existing cirrhosis vs no cirrhosis
- Cirrhosisn = 371
- Outcome
- Clinical outcomes and biological characteristics that differ between patients with and without cirrhosis
Methodological detailssingle-centre, multivariable logistic regression adjusted for pre-specified confounders
- Single-centre
- Multivariable logistic regression adjusted for pre-specified confounders
Main finding
As reported in the abstract
Acute kidney injury (AKI) (6 days), 30-day mortality and ARDS (6 days), cirrhosis vs no cirrhosis
Cirrhosis vs No cirrhosisAdjusted odds ratio (95% CI)P value
AKI
1.65(1.21–2.26)
P = 0.00230-day mortality
1.38(1.05–1.82)
P = 0.022- No significant difference in acute respiratory distress syndrome (ARDS) risk
- adjusted OR 1.02; 95% CI 0.69 to 1.50; P = 0.92
Observational data: associations, not effects.
Further findings
Plasma proteins at ICU admission (subset)
- Higher angiopoietin-2 with cirrhosis
- P < 0.001
- Higher von Willebrand factor with cirrhosis
- P < 0.001
- Higher soluble thrombomodulin with cirrhosis
- P < 0.001
- Lower IL-10 with cirrhosis
- P < 0.001
- Lower IL-1β with cirrhosis
- P = 0.008
- Lower IL-1RA with cirrhosis
- P = 0.036
- No significant difference in IL-6
- P = 0.30
- Wilcoxon rank-sum test
Baseline characteristics
- Cirrhosis: higher severity of illness scores, more abdominal source of sepsis, more significant coagulation abnormalities
Original publication
Identifying a unique signature of sepsis in patients with pre-existing cirrhosis. Crit Care. Published 19 May 2025. doi:10.
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