Haemodynamics, fluids & transfusion
Impact of Hypovolemic Phlebotomy With Low Central Venous Pressure on Intraoperative Blood Loss in Open Liver Resection: A Double-Blind Randomized Controlled Trial
Authors' conclusion
HP significantly reduces intraoperative blood loss and enhances bleeding control by achieving a low CVP more quickly.
Study context
- Population
- Patients undergoing open liver resectionrandomised
- Participants
- 100 patients
- Comparison
- Hypovolemic phlebotomy vs conventional management to achieve low central venous pressure (CVP)
- Primary endpoint
- Intraoperative blood loss
Methodological detailsprospective, Conducted 2020–2024
- Prospective
- Conducted 2020–2024
Primary result
Blood loss during parenchymal transection
Difference
150
95% CI 50–275
P = 0.02
By group
HP vs Control
difference 150 (95% CI 50–275); P = 0.02
As reported in the abstract
Secondary outcomes
| Outcome | HP | Control | Difference (95% CI) | P value | |
|---|---|---|---|---|---|
| Time to achieve low CVP | 50 (range 30–100) minutes | 107.5 (range 45–150) minutes | −75.0 (−95.0 to −56.0) | P = 0.01 | |
| Surgical bleeding score | 2 (range 1–3) | 2 (range 2–4) | −1.0 (−1.0 to −0.5) | P = 0.01 | |
| −100−50050Difference (linear scale) |
| Outcome | aOR (95% CI) | P value | |
|---|---|---|---|
| Blood loss >500 mL (multivariable)Independent protective factor | 0.19 (0.04–0.80) | P = 0.02 | |
| 0.050.21520Adjusted odds ratio (log scale) |
Transfusion rates
- Similar in the two groups
Safety
Postoperative complications
- Similar in the two groups
Original publication
Impact of Hypovolemic Phlebotomy With Low Central Venous Pressure on Intraoperative Blood Loss in Open Liver Resection: A Double-Blind Randomized Controlled Trial. Ann Surg. Published 21 May 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →