Impact of Age on the Occurrence of Processed Electroencephalographic Burst Suppression
Authors' conclusion
The probability of burst suppression during general anesthesia increases linearly with age in adult patients, while lower anesthetic concentrations induce burst suppression with increasing patient age. Simultaneously, algorithm-based burst suppression detection appears to perform worse in older patients.
Study context
- Population
- Adults (≥18 years) receiving GA, January 2016–December 201854,266 analysed
- Participants
- 38,628 adults
- Outcome
- Incidence of burst suppression (Entropy Module BSR >0) and its association with age
Methodological detailssingle-centre, university hospital
- Single-centre
- University hospital
Main finding
As reported in the abstract
Patients with burst suppression ratio (BSR) >0
19,079
Patients with BSR >0 significantly older; age had highest predictive power for BSR >0 (AUROC)
0.646
0.638–0.654
Probability of BSR >0 increased linearly with age (ρ)
0.96-0.99
Increase in probability of BSR >0 per year
between 1.9% and 9.8%
Observational data: associations, not effects.
Further findings
Maximal and mean BSR
- Nonlinear relationship with age
Relative burst suppression duration during maintenance
- Increased linearly with age (ρ)
- 0.83
Potential burst suppression episodes not detected by Entropy BSR algorithm
- More frequent with age
Volatile anesthetic concentration inducing BSR >0
- Negatively correlated with age, sevoflurane (ρ)
- −0.71
- Remained close to an age-adjusted minimum alveolar concentrations (aaMAC) of
- 1.0
Original publication
Composed by AI from the published abstract and checked against it. How Briefs are made →