Cardiothoracic & vascular anesthesia
Incidence of Concurrent Cerebral Desaturation and Electroencephalographic Burst Suppression in Cardiac Surgery Patients
Main finding · Burst suppression with cerebral desaturationResult — go to the resultOdds ratio 1.52 95% CI 1.11–2.07Authors' conclusion
Cerebral desaturation is associated with intraoperative burst suppression during cardiac surgery, most significantly during CPB, especially during the period between the removal of the aortic cross-clamp and end of CPB.
Study context
- Population
- Patients undergoing cardiac surgery
- Participants
- 51 patients
- Exposure
- Cerebral desaturation vs no desaturation; CPB and post-CPB vs pre-CPB
- Outcome
- Association between cerebral desaturation (10% decrease from baseline) and EEG burst suppression
Methodological details1-minute interval observations, anesthesiologists blinded to processed EEG and cerebral oximetry, generalized logistic mixed effect model
- 1-minute interval observations
- Anesthesiologists blinded to processed EEG and cerebral oximetry
- Generalized logistic mixed effect model
Main finding
Burst suppression with cerebral desaturation
Odds ratio
1.52
95% CI 1.11–2.07
P = 0.009
Cerebral desaturation vs No cerebral desaturation
OR 1.52 (95% CI 1.11–2.07); P = 0.009
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | OR (95% CI) | P value | |
|---|---|---|---|
| Cerebral desaturation by surgical phaseCPB vs pre-CPB | 22.1 (12.4–39.2) | P < 0.001 | |
| Cerebral desaturation by surgical phasepost-CPB vs pre-CPB | 18.2 (12.2–27.3) | P < 0.001 | |
| Burst suppression by surgical phasepost-CPB vs pre-CPB | 0.69 (0.59–0.81) | P < 0.001 | |
| Concurrent cerebral desaturation and burst suppression by surgical phaseCPB vs pre-CPB | 52.3 (19.5–140) | P < 0.001 | |
| Concurrent cerebral desaturation and burst suppression by surgical phasepost-CPB vs pre-CPB | 12.7 (6.39–25.2) | P < 0.001 | |
| Burst suppression with higher inhalational anesthesia concentration · entire surgeryPer 0.1% increase | 7.81 (6.26–9.74) | P < 0.001 | |
| 0.050.21520Odds ratio (log scale) |
During CPB: aortic cross-clamp removal to end of CPB period
| Estimate | P value | ||
|---|---|---|---|
| Cross-clamp removal to end of CPB | OR (cerebral desaturation) 6.59 (95% CI 3.62–12) | P < 0.001 | |
| Cross-clamp removal to end of CPB | OR (concurrent desaturation and burst suppression) 10 (95% CI 4.01–25.1) | P < 0.001 | |
| 0.050.21520Ratio (log scale) |
Original publication
Incidence of Concurrent Cerebral Desaturation and Electroencephalographic Burst Suppression in Cardiac Surgery Patients. Anesth Analg. Published 1 May 2025. doi:10.
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