Impact of age on the reliability of GE Entropy™ module indices for guidance of maintenance of anaesthesia in adult patients: a single-centre retrospective analysis
Authors' conclusion
Despite their intuitive appeal, the processed EEG index values SE, RE, ΔRE-SE, and BSR showed limited reliability in guiding maintenance of anaesthesia, especially in older patients.
Study context
- Population
- Adults (18–90 yr) undergoing GA monitored with the GE Entropy module15,608 records analysed
- Participants
- 14,770 adults
- Outcome
- Age-dependent effects on processed Entropy index values
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
- SE values within the recommended range during steady-state anaesthesia (burst suppression ratio (BSR)=0), most below target
- 38.4% (32.5-42.4%)
- Age vs age-adjusted MAC of volatile anaesthetics: adj. R2=0.18, P<0.001
- rho=0.47 [0.20-0.70]
- Age vs SE (SE paradoxically increased with age): adj. R2=0.45, P<0.001
- rho=0.67 [0.51-0.79]
- Age vs SE during periods with positive BSR: adj. R2=0.73, P<0.001
- rho=0.90 [0.80-0.95]
- Age vs frequency of ΔRE-SE≥10 (arousal): adj. R2=0.70, P<0.001
- rho=0.92 [0.85-0.95]
- Age vs duration of ΔRE-SE≥10 (arousal): adj. R2=0.73, P<0.001
- rho=0.89 [0.82-0.93]
Observational data: associations, not effects.
Original publication
Impact of age on the reliability of GE Entropy™ module indices for guidance of maintenance of anaesthesia in adult patients: a single-centre retrospective analysis. Br J Anaesth. Published 6 February 2025. doi:10.
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