Impact of Chronic Hepatitis C Virus on Acute Kidney Injury After Living Donor Liver Transplantation
Main finding · AKIResult — go to the resultOdds ratio 1.53 95% CI 1.06–2.20Authors' conclusion
The presence of HCV was associated with increased risk for the development of AKI, 1-year mortality, and graft failure after LT.
Study context
- Population
- Patients who underwent living donor liver transplantation (LT) (living donor LT (LDLT)), January 2008 to April 2023
- Participants
- 2,183 patients
- Exposure
- Chronic hepatitis C virus (HCV) infection vs no HCV in LDLT recipients
- Outcome
- AKI development after LT
Methodological detailspropensity-score matched
- Propensity-score matched
Main finding
AKI
Odds ratio
1.53
95% CI 1.06–2.20
P = 0.022
By group
HCV vs No HCV
OR 1.53 (95% CI 1.06–2.20); P = 0.022
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | HR (95% CI) | P value | |
|---|---|---|---|
| Mortality · 1 yearMultivariate analysis after PSM | 1.98 (1.12–3.52) | P = 0.019 | |
| Graft failure · 1 yearMultivariate analysis after PSM | 2.12 (1.22–3.69) | P = 0.008 | |
| 0.20.5125Hazard ratio (log scale) |
Acute kidney injury (AKI) incidence, all patients
- Incidence of AKI among 2183 patients
- 59.2%
Original publication
Impact of Chronic Hepatitis C Virus on Acute Kidney Injury After Living Donor Liver Transplantation. Anesth Analg. Published 16 October 2024. doi:10.
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