Impact of Empirical Treatment Recommendations From 2017 European Guidelines for Nosocomial Pneumonia
Authors' conclusion
Our findings indicate that the European guideline treatment algorithm is effective in reducing mortality in patients without septic shock but not in those with septic shock at the time of diagnosis.
Study context
- Population
- ICU patients with microbiologically confirmed nosocomial pneumoniaof 507 in cohort
- Participants
- 315 patients
- Exposure
- Guideline adherence vs No guideline adherence
- Outcome
- 28-day mortality
- Follow-up
- 28 days
Methodological detailssingle-centre, 6 ICUs
- Single-centre
- 6 ICUs
Main finding
As reported in the abstract
- Outcomes comparable with and without guideline adherence (except overtreatment)
Observational data: associations, not effects.
Secondary outcomes
Overtreatment
- Overtreatment: P < .001
Overtreatment
- Overtreatment higher when guidelines followed
90-day mortality, ICU mortality, inadequate treatment, treatment failure
- Comparable with and without guideline adherence
ICU mortality (subgroup without septic shock)
- Reduced ICU mortality when treated according to guidelines
- P = .031
Adjusted 28-day mortality (subgroup without septic shock)
- Reduction in adjusted 28-day mortality when treated according to guidelines: HR
- 3.07 (95% CI 1.13-7.85; P = .027)
Mortality (subgroup with septic shock at diagnosis)
- No benefit with septic shock at diagnosis
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Impact of Empirical Treatment Recommendations From 2017 European Guidelines for Nosocomial Pneumonia. Chest. Published 24 October 2024. doi:10.
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