Hemodynamics, fluids & transfusion
Impact of fluid expansion on ventriculo-arterial coupling during circulatory failure
Authors' conclusion
In acute circulatory failure, the effects of FE on VAC depend on preload responsiveness. Responders exhibit improved VAC driven by reduced Ea, while non-responders show increased Ea without significant VAC modification. Ees remains unaffected in both groups.
Study context
- Population
- ICU patients with acute circulatory failure requiring fluid expansion (FE), France17 (45%) fluid responders
- Participants
- 38 patients
- Exposure
- Before vs after FE; fluid responders vs non-responders
- Respondersn = 17
- Outcome
- Effects of FE on VAC and its components (Ea, Ees), by preload responsiveness
Methodological detailssingle-centre, Transthoracic echocardiography before and after FE; Ventriculo-arterial coupling (VAC), elastance (Ea), Ees by single-beat method
- Single-centre
- Transthoracic echocardiography before and after FE; VAC, Ea, Ees by single-beat method
Main finding
As reported in the abstract
VAC, Ea, Ees before vs after FE
- Responders: Ea decreased 1.63 [1.19-2.05] to 1.46 [1.10-1.96]
- p = 0.0007
- Non-responders: Ea increased 1.31 [0.99-1.67] to 1.37 [1.02-1.78]
- p = 0.003
- Responders: VAC improved 1.26 [0.82-1.63] to 1.09 [0.79-1.43]
- p = 0.03
Observational data: associations, not effects.
Further findings
Baseline Ea, Ees, VAC
- Responders had higher Ea and Ees than non-responders; VAC comparable between groups
Original publication
Impact of fluid expansion on ventriculo-arterial coupling during circulatory failure. J Crit Care. Published 16 April 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →