ICU sedation, delirium & recovery

Impact of High-Dose Early Mobilization on Outcomes for Patients with Diabetes: A Secondary Analysis of the TEAM Trial

Am J Respir Crit Care MedPublished Secondary analysis of the TEAM randomised trial

Authors' conclusion

In this secondary analysis of the TEAM trial, in patients with diabetes, a high-dose early mobilization strategy did not significantly decrease the number of days alive and out of the hospital at Day 180, but it increased 180-day mortality.

Study context

Population
ICU patients of the TEAM trial
Participants
741 patients
Comparison
High-dose early mobilization by diabetes status
  • Diabetesn = 159
Primary endpoint
Days alive and out of hospital
Follow-up
Day 180
Methodological detailssubgroup analysis by diabetes status
  • Subgroup analysis by diabetes status

Primary result

As reported in the abstract

Days alive and out of hospital with high-dose early mobilization

Secondary outcomes

Days alive and out of hospital, overall by diabetes status · Day 180

P = 0.013

Mortality, overall by diabetes status · 180 days

P = 0.044

Mortality with high-dose early mobilization (diabetes subgroup) · 180 days

aOR (95% CI)
High-dose early mobilizationPatients with diabetes3.47 (1.67–7.61)
  • Mortality with high-dose early mobilization (diabetes subgroup): P value for interaction = 0.001

Original publication

Impact of High-Dose Early Mobilization on Outcomes for Patients with Diabetes: A Secondary Analysis of the TEAM Trial. Am J Respir Crit Care Med. Published 15 September 2024. doi:10.1164/rccm.202312-2289oc

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