Impact of renal vein doppler ultrasound-guided central venous pressure (CVP) titration in sepsis: a pilot randomized controlled trial
Authors' conclusion
In this pilot randomized controlled trial, renal vein Doppler ultrasound-guided CVP titration was feasible and was associated with greater de-escalation and a lower fluid balance.
Study context
- Population
- Adults with sepsis and CVP monitoring in an ICU, April–December 2023173 screened
- Participants
- 127 adults
- Comparison
- Renal vein Doppler-guided CVP titration vs usual care
- RVD-CVPn = 63
- Usual caren = 64reference
- Primary endpoint
- Feasibility: complete protocol delivery in the intervention group
Methodological detailspilot, prospective, single-centre, parallel-group
- Pilot
- Prospective
- Single-centre
- Parallel-group
Primary result
As reported in the abstract
Complete protocol delivery, intervention patients
100.0%
63/63; 95% CI, 94.3–100.0
Scheduled renal vein Doppler assessments completed (315/315)
100.0%
Secondary outcomes
AKI progression within 7 days (exploratory)
- Control 37/64 vs intervention 27/63
- 57.0% vs. 43.0%
- RR
- 0.74 (95% CI 0.52-1.06)
- Exploratory
RRT initiation (exploratory)
- Intervention vs control
- 9.52% vs. 23.44%
- RR
- 0.41 (95% CI 0.17-0.98, P = 0.035)
- Exploratory
Duration of RRT (exploratory)
- Intervention vs control (P = 0.03)
- 0.84 days vs. 2.39 days
- Exploratory
Mortality (exploratory) · 28 days
- Intervention vs control
- 7.9% vs. 12.5%
- Exploratory
Vasopressor-free days at day 28 (exploratory)
- Intervention vs control, mean (days)
- 22.12 vs. 18.84
- Exploratory
Maximum norepinephrine dose (exploratory)
- Intervention vs control, mean (µg/kg/min)
- 0.423 vs. 0.560
- Exploratory
Safety
Safety-override deferrals
- Deferrals in 17/315 assessments
- 5.4%
Original publication
Impact of renal vein doppler ultrasound-guided CVP titration in sepsis: a pilot randomized controlled trial. Crit Care. Published 24 January 2026. doi:10.
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