Impact of therapeutic plasmapheresis on the duration of organ failure in patients with hypertriglyceridemia-associated acute pancreatitis
Authors' conclusion
In HTG-AP patients with early organ failure, plasmapheresis was not associated with accelerated organ failure resolution compared to medical treatment but may be associated with more ICU admissions.
Study context
- Population
- HTG-AP patients admitted within 72 h of symptom onset with organ failure at enrollment, PERFORM registry, November 2020 to March 2023
- Participants
- 122 patients
- Exposure
- Plasmapheresis vs medical treatment
- Plasmapheresisn = 46
- Medical treatmentn = 76reference
- Outcome
- Time to organ failure resolution
- Follow-up
- Within 14 days
Methodological detailsmulticentre registry, multivariable Cox regression, directed acyclic graph for confounder selection
- Multicentre registry
- Multivariable Cox regression
- Directed acyclic graph for confounder selection
Main finding
As reported in the abstract
Time to organ failure resolution within 14 days · 14 days
- No significant difference in time to organ failure resolution between plasmapheresis and exclusive medical treatment
- Multivariable Cox regression
Observational data: associations, not effects.
Further findings
| Outcome | Plasmapheresis | Medical treatment | OR (95% CI) | P value | |
|---|---|---|---|---|---|
| ICU requirement | 97.8% | 65.8% | 19.33 (2.20–169.81) | P = 0.008 | |
| 0.050.21520Odds ratio (log scale) |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Impact of therapeutic plasmapheresis on the duration of organ failure in patients with hypertriglyceridemia-associated acute pancreatitis. Ann Intensive Care. Published 15 April 2024. doi:10.
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