Cardiothoracic & vascular anesthesia
Incidence and Characteristics of Residual Heparin Effect in Cardiothoracic Surgical Patients using Sonorheometry Clot Time Ratio
Authors' conclusion
Clinically significant residual heparinization was rare in the early postoperative period among cardiac surgical patients with suspected coagulopathy based on sonorheometry CTR.
Study context
- Population
- Adults undergoing cardiac surgery with CPB with suspected postoperative coagulopathy, single academic medical center
- Participants
- 502 adults
- Exposure
- Sonorheometry vs No sonorheometry
- Sonorheometryn = 175
- No sonorheometryn = 327reference
- Outcome
- CTR elevation (>1.4)
- Follow-up
- Early postoperative
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Clot time ratio (CTR) measured
2.9%
5 events
Observational data: associations, not effects.
Further findings
Significant postoperative bleeding (24-h chest tube output > 1 L or postoperative RBC transfusion)
P < 0.0001
Correlation of CTR with protamine to heparin ratio (PHR)
- Negative correlation with loading PHR, R2 (p < 0.0001)
- 0.2206
- Negative correlation with cumulative PHR, R2 (p < 0.0001)
- 0.2050
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Incidence and Characteristics of Residual Heparin Effect in Cardiothoracic Surgical Patients using Sonorheometry Clot Time Ratio. J Cardiothorac Vasc Anesth. Published 30 May 2026. doi:10.
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