Incidence of hospital-acquired infections due to carbapenem-resistant Enterobacterales and Pseudomonas aeruginosa in critically ill patients in Italy: a multicentre prospective cohort study
Authors' conclusion
These results highlight the high prevalence of CRE/CRPA infections in Italian ICUs
Study context
- Population
- Patients with hospital-acquired Carbapenem-Resistant Enterobacterales (CRE) or Carbapenem-Resistant Pseudomonas aeruginosa (CRPA) infections in 20 Italian intensive care units (ICUs), June 2021 to February 2023158 in full analysis
- Participants
- 13,088 patients
- Exposure
- CRE vs CRPA
- CREn = 283
- CRPAn = 138
- Outcome
- Incidence of CRE/CRPA infections
- Follow-up
- 1 year
Methodological detailsobservational, multicentre
- Observational
- Multicentre
Main finding
As reported in the abstract
Incidence of infections · 12-month study period
Observational data: associations, not effects.
Secondary outcomes
Proportion of all Enterobacterales / P. aeruginosa infections that were carbapenem-resistant
Crude ICU mortality
- Crude ICU mortality — Overall crude ICU mortality
- 30.4%
Infection type (full analysis, n=158)
- Ventilator-associated pneumonia
- 53.8%
- Bloodstream infections
- 34.2%
Inappropriate empirical therapy targeting gram-negative pathogens
- Inappropriate empirical therapy (77/130)
- 59.2%
Clinical success, including microbiological eradication
- Clinical success
- 50.6%
Microbiological characterization
- Klebsiella pneumoniae predominant CRE species; all CRE isolates, including MBL-CRE, susceptible to Aztreonam-Avibactam
Original publication
Incidence of hospital-acquired infections due to carbapenem-resistant Enterobacterales and Pseudomonas aeruginosa in critically ill patients in Italy: a multicentre prospective cohort study. Crit Care. Published 17 January 2025. doi:10.
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