Respiratory failure & ventilation
Incidence and outcomes of extubation failure in mechanically ventilated patients with cirrhosis: a post-hoc analysis of a prospective multicenter study
Authors' conclusion
Extubation failure was significantly higher in patients with cirrhosis compared to patients without cirrhosis.
Study context
- Population
- Mechanically ventilated intensive care unit (ICU) patients liberated from invasive mechanical ventilationanalysed
- Participants
- 1,443 participants
- Comparison
- Patients with cirrhosis vs without cirrhosis
- Cirrhosisn = 165
- No cirrhosisn = 1,278reference
- Primary endpoint
- Extubation failure (need for reintubation within 7 days after extubation)
- Follow-up
- 7 days
Methodological detailspost hoc analysis, 26 ICUs
- Post hoc analysis
- 26 ICUs
Primary result
As reported in the abstract
Reintubation within 7 days
P < 0.01
Secondary outcomes
Reintubation at 48 h · not significantly different
P = 0.55
In-hospital mortality in patients with extubation failure · without reaching significance
P = 0.06
Risk factor for extubation failure: admission for shock (multivariate analysis)
| OR (95% CI) | P value | ||
|---|---|---|---|
| Admission for shockOnly independent risk factor | 3.24 (1.24–8.44) | P = 0.02 | |
| 0.10.31310Odds ratio (log scale) |
ICU LOS in patients with extubation failure · significantly longer with cirrhosis
P < 0.01
Original publication
Incidence and outcomes of extubation failure in mechanically ventilated patients with cirrhosis: a post-hoc analysis of a prospective multicenter study. Ann Intensive Care. Published 16 October 2025. doi:10.
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