Respiratory failure & ventilation
Incidence, Risk Factors, and Long-Term Outcomes for Extubation Failure in ICU in Patients With Obesity: A Retrospective Analysis of a Multicenter Prospective Observational Study
Main finding · Extubation failure within 48 hResult — go to the resultOdds ratio 0.71 95% CI 0.45–1.13Authors' conclusion
Our findings indicate that anticipation and application of preventive measures for patients with obesity before and after extubation led to similar rates of extubation failure among patients with and without obesity.
Study context
- Population
- Unselected critically ill adults extubated in 26 ICUs (FREEREA study)extubation procedures analysed
- Participants
- 1,370 adults
- Exposure
- Patients with vs without obesity
- Obesityn = 288
- No obesityn = 1,082reference
- Outcome
- Extubation failure
- Follow-up
- Within 48 h
Methodological detailsmulticentre, observational
- Multicentre
- Observational
Main finding
Extubation failure within 48 h · 48 h
Odds ratio
0.71
95% CI 0.45–1.13
P = 0.15
Events by group
Obesity vs No obesity
OR 0.71 (95% CI 0.45–1.13); P = 0.15
As reported in the abstract
Observational data: associations, not effects.
Secondary outcomes
Use of NIV after extubation
P = 0.002
Physiotherapy
P = 0.02
Risk factors for extubation failure (Obesity subgroup)
| aOR (95% CI) | P value | ||
|---|---|---|---|
| Female sex | 4.88 (1.61–13.9) | P = 0.002 | |
| Agitation before extubation | 6.39 (1.91–19.8) | P = 0.001 | |
| 0.050.21520Adjusted odds ratio (log scale) |
Risk factors for extubation failure (No obesity subgroup)
| aOR (95% CI) | P value | ||
|---|---|---|---|
| Absence of strong cough before extubation | 2.38 (1.53–3.84) | P = 0.0002 | |
| 0.20.5125Adjusted odds ratio (log scale) |
| Outcome | aOR (per day) (95% CI) | P value | |
|---|---|---|---|
| Risk factors for extubation failure (No obesity subgroup)Duration of invasive mechanical ventilation before extubation | 1.03 (1.01–1.06) | P = 0.01 | |
| 0.512Adjusted odds ratio (log scale) |
Decision tree analysis
- Similar risk factors found
Original publication
Incidence, Risk Factors, and Long-Term Outcomes for Extubation Failure in ICU in Patients With Obesity: A Retrospective Analysis of a Multicenter Prospective Observational Study. Chest. Published 7 September 2024. doi:10.
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