Respiratory failure & ventilation
Norepinephrine use at extubation in critically ill patients with obesity: a cohort study with multicenter validation
Authors' conclusion
In critically ill patients with obesity, the use of norepinephrine at the time of extubation did not significantly increase the reintubation rates.
Study context
- Population
- Critically ill patients with obesityobesity, main cohort of 3186
- Participants
- 837 patients
- Exposure
- Norepinephrine vs no norepinephrine at extubation
- Norepinephrinen = 213
- Outcome
- Reintubation
- Follow-up
- 7 days
Methodological detailsprospectively collected data, multicenter validation cohort
- Prospectively collected data
- Multicenter validation cohort
Main finding
As reported in the abstract
Reintubation (main cohort)
P = 0.85
Observational data: associations, not effects.
Secondary outcomes
Reintubation, validation cohort (656 with obesity)
P = 0.45
- Norepinephrine dose at extubation
- 0.097 · median · range 0.04–0.17 · µg/kg/min of real body weight
Reintubation, patients without obesity (n 2349)
- Similar results
Original publication
Norepinephrine use at extubation in critically ill patients with obesity: a cohort study with multicenter validation. Intensive Care Med. Published 6 August 2025. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →