Perioperative medicine & outcomes
Incidence of postoperative delirium and quality of recovery in older patients undergoing gastrectomy under general anaesthesia with remimazolam vs. propofol: a randomised non‐inferiority study
Primary resultResult — go to the resultUnadjusted odds ratio 1.00 95% CI 0.50–2.02Authors' conclusion
Remimazolam can be used as an alternative to propofol in older patients undergoing gastrectomy from the perspective of the incidence of postoperative delirium and quality of recovery.
Study context
- Population
- Patients aged ≥ 65 y scheduled to undergo gastrectomy432 analysed
- Participants
- 461 patients
- Comparison
- Remimazolam infusion vs propofol TCI for maintenance of GA
- Remimazolamn = 216
- Propofoln = 216reference
- Primary endpoint
- Incidence of delirium (confusion assessment method)
- Follow-up
- Within 72 h of surgery
Methodological detailsnon-inferiority
- Non-inferiority
Primary result
As reported in the abstract
Unadjusted odds ratio
1.00
95% CI 0.50–2.02
P = 1.000
Events by treatment group
Remimazolam vs Propofol
unadjusted OR 1.00 (95% CI 0.50–2.02); P = 1.000
Secondary outcomes
Median
| Outcome | Remimazolam | Propofol | Unadjusted odds ratio (95% CI) | P value |
|---|---|---|---|---|
| Quality of recovery (Korean QoR-15) · 24 h postoperatively | 109 (IQR [range] 102-115 [54-140]) | 109 (IQR [range] 104-115 [70-137]) | −0.03 (−0.19-0.13) | P = 0.627 |
Original publication
Incidence of postoperative delirium and quality of recovery in older patients undergoing gastrectomy under general anaesthesia with remimazolam vs. propofol: a randomised non‐inferiority study. Anaesthesia. Published 14 July 2025. doi:10.
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