Cardiothoracic & vascular anesthesia
Indexed Delivery of Oxygen Predicts In-hospital Mortality and Morbidity in Reoperative Adult Cardiac Surgery Patients: A Retrospective Cohort Study
Authors' conclusion
Reduced intraoperative DO₂i was independently associated with increased risk of mortality and major morbidity following reoperative cardiac surgery.
Study context
- Population
- Adults undergoing reoperative cardiac surgery with cardiopulmonary bypass (CPB) at a tertiary academic centre, January 2011 to January 2021
- Participants
- 343 adults
- Exposure
- Low vs high intraoperative DO₂i during CPB
- Outcome
- In-hospital mortality
Methodological detailssingle-centre, inverse-probability-of-treatment weighting
- Single-centre
- Inverse-probability-of-treatment weighting
Main finding
As reported in the abstract
Odds ratio (95% CI)
DO₂i below the thresholdfourfold higher mortality risk
4.12(1.18–9.49)
Each 1 mL/min/m² decrease in DO₂imultivariable analysis; mortality risk +1.6%
1.016(1.007–1.024)
Each 1 mL/min/m² decrease in DO₂i, as printed
- Overall in-hospital mortality
- 14.6%
- Median DO₂i <289.4 mL/min/m² predicted mortality: AUC
- 0.756
- Sensitivity
- 78%
- Specificity
- 64%
Observational data: associations, not effects.
Further findings
Cardiac morbidity · after IPTW
P < 0.001
Prolonged ventilation · after IPTW
P = 0.015
| Outcome | P value |
|---|---|
| AKIHigher in Low DO₂i; after IPTW | P = 0.042 |
DO₂i during CPB
- Median DO₂i (as printed, ± 52.3)
- 300.8 mL/min/m²
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Indexed Delivery of Oxygen Predicts In-hospital Mortality and Morbidity in Reoperative Adult Cardiac Surgery Patients: A Retrospective Cohort Study. J Cardiothorac Vasc Anesth. Published 3 January 2026. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →