Cardiac arrest & resuscitation
Inflammatory response after out‐of‐hospital cardiac arrest—Impact on outcome and organ failure development
Authors' conclusion
Inflammatory markers are potentially useful for early risk stratification after OHCA. PCT and IL-6 have moderate prognostic value during the first 24 h of the ICU stay. Predictive accuracy appears to be associated with the study overall event rate.
Study context
- Population
- Adult out-of-hospital cardiac arrest (OHCA) patients with inflammatory markers measured59 studies · 65 markers
- Comparison
- IL-6 vs procalcitonin (PCT) vs C-reactive protein (CRP)
- Outcome
- Prognostic capability of inflammatory markers for mortality, neurological outcome or organ failure severity
Main finding
As reported in the abstract
Association with poor outcome and discrimination (AUC) for poor outcome
| Group | Value | Studies showing association with poor outcome | Best time point | Studies reporting AUC |
|---|---|---|---|---|
| IL-6 | median AUC 0.78 (range 0.71–0.98) | 13/15 | ICU admission | |
| PCT | median AUC 0.84 (range 0.61–0.98) | 13/14 | day one after OHCA | |
| CRP | 11/17 | 7 |
Value
IL-6median AUC 0.78 (range 0.71–0.98)
PCTmedian AUC 0.84 (range 0.61–0.98)
CRP— not stated in the abstract
Studies showing association with poor outcome
IL-613/15
PCT13/14
CRP11/17
Best time point
IL-6ICU admission
PCTday one after OHCA
CRP— not stated in the abstract
Studies reporting AUC
IL-6— not stated in the abstract
PCT— not stated in the abstract
CRP7
Further findings
- Conflicting results regarding each marker's association with organ failure severity
Original publication
Inflammatory response after out‐of‐hospital cardiac arrest—Impact on outcome and organ failure development. Acta Anaesthesiol Scand. Published 20 June 2023. doi:10.
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