Cardiac arrest & resuscitation
Intestinal injury in cardiac arrest is associated with multiple organ dysfunction: A prospective cohort study
Authors' conclusion
Cardiac arrest duration and lactate serum concentrations were risk factors for intestinal injury. High levels of IFABP at admission were associated with multiple organ dysfunction and mortality.
Study context
- Population
- Patients admitted to intensive care unit (ICU) after out-of-hospital cardiac arrest (OHCA)
- Participants
- 50 patients
- Exposure
- High vs low Intestinal Fatty Acid Binding Protein (IFABP) at ICU admission
- Outcome
- Associations of clinical characteristics with IFABP (intestinal injury biomarker); associations of IFABP with multiple organ dysfunction and 30-day mortality
Main finding
As reported in the abstract
Determinants of IFABP (multivariable model)
- Duration of arrest contributed to elevated IFABP
- p < 0.01
- Lactate serum concentration contributed to elevated IFABP
- p = 0.04
Observational data: associations, not effects.
Further findings
| Outcome | OR | P value |
|---|---|---|
| 30-day mortality · per SD increase | 16.9 | P = 0.04 |
Death and transfer to ward by day two
- All patients who had died were in the high IFABP group
- 7
- All patients transferred to ward were in the low IFABP group
- 6
Sequential Organ Failure Assessment (SOFA) score and inotropes among patients still in ICU · day two
- High IFABP had higher total, renal and respiratory SOFA score
- P < 0.01
- High IFABP group included all patients receiving inotropic drugs
Original publication
Intestinal injury in cardiac arrest is associated with multiple organ dysfunction: A prospective cohort study. Resuscitation. Published 25 February 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →