Influence of Clinical and Genetic Factors on Propofol Dose Requirements: A Genome-wide Association Study
Authors' conclusion
In this first genome-wide association study exploring propofol requirements, This study discovered novel genetic associations suggesting new biologically relevant pathways for propofol and general anesthesia.
Study context
- Population
- Women undergoing breast cancer surgery under propofol and remifentanil anaesthesia, depth monitored with State Entropy
- Participants
- 1,000 women
- Outcome
- Propofol requirements during surgery
Methodological detailsmultivariable linear regression, imputed genotype data, in silico functional annotation
- Multivariable linear regression
- Imputed genotype data
- In silico functional annotation
Main finding
As reported in the abstract
Genetic associations with propofol requirements
- Two loci reached genome-wide significance
- P < 5 × 10-8
- rs10512538 near KCNJ2 (Kir2.1 potassium channel): suggestive association
- P = 4.7 × 10-7
Further findings
Clinical factors (multivariable model)
- BMI, smoking status, alcohol use, remifentanil dose and average State Entropy during surgery remained statistically significant
Previously reported candidate-gene SNPs (propofol pharmacokinetics or pharmacodynamics)
- None showed association in the data
Original publication
Influence of Clinical and Genetic Factors on Propofol Dose Requirements: A Genome-wide Association Study. Anesthesiology. Published 3 May 2024. doi:10.
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