Perioperative medicine & outcomes
Influence of elevated liver enzyme level on 30-day mortality rates in patients undergoing nonemergency orthopedic surgery
Main finding · 30-day postoperative mortalityResult — go to the resultAdjusted hazard ratio 1.62 95% CI 1.39–1.90Authors' conclusion
Elevated preoperative SGOT levels constitute an independent risk factor for 30-day postoperative mortality and are proportionately associated with the risk of 30-day postoperative mortality.
Study context
- Population
- Adults undergoing nonemergency orthopedic surgery under GA, ACS NSQIP database, 2011–20216.1% elevated serum glutamic oxaloacetic transaminase (SGOT)
- Participants
- 477,524 adults
- Exposure
- Elevated vs normal preoperative SGOT
- Elevated SGOTn = 24,197
- Outcome
- Postoperative mortality
- Follow-up
- 30 days
Methodological detailsregistry database (ACS NSQIP), propensity score matching
- Registry database (ACS NSQIP)
- Propensity score matching
Main finding
30-day postoperative mortality
Adjusted hazard ratio
1.62
95% CI 1.39–1.90
Elevated SGOT vs Normal SGOT
aHR 1.62 (95% CI 1.39–1.90)
As reported in the abstract
Observational data: associations, not effects.
Further findings
30-day postoperative mortality after propensity score matching
- Results unchanged after propensity score matching
Original publication
Influence of elevated liver enzyme level on 30-day mortality rates in patients undergoing nonemergency orthopedic surgery. Perioper Med (Lond). Published 6 May 2024. doi:10.
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