Influence of fluid accumulation on major adverse kidney events in critically ill patients – an observational cohort study
Main finding · MAKE30Result — go to the resultAdjusted odds ratio 1.96 95% CI 1.67–2.30Authors' conclusion
Fluid accumulation is significantly associated with MAKE30 in critically ill patients. This association is independent from pre-existing CKD and strongest in patients with AKI stage 3.
Study context
- Population
- Adult intensive care unit (ICU) patients with sufficient data to compute fluid accumulation (FA) and MAKE301,100 (8.3%) met FA definition
- Participants
- 13,326 patients
- Exposure
- Fluid accumulation vs no FA at ICU day 3
- FAn = 1,100
- Outcome
- Major adverse kidney events in the first 30 days after ICU admission (MAKE30)
- Follow-up
- 30 days
Methodological detailssingle-centre
- Single-centre
Main finding
MAKE30
Adjusted odds ratio
1.96
95% CI 1.67–2.30
P < 0.001
FA vs No FA
aOR 1.96 (95% CI 1.67–2.30); P < 0.001
As reported in the abstract
Observational data: associations, not effects.
Further findings
| Outcome | aOR (95% CI) | P value | |
|---|---|---|---|
| Need for RRT | 3.83 (3.02–4.84) | p all < 0.001 | |
| Persistent renal dysfunction | 1.72 (1.40–2.12) | p all < 0.001 | |
| 30-day mortality | 1.70 (1.38–2.09) | p all < 0.001 | |
| 0.20.5125Adjusted odds ratio (log scale) |
MAKE30 by chronic kidney disease (CKD) and AKI stage (sensitivity analysis)
- Association of FA with MAKE30 independent of pre-existing CKD, but exclusively in patients with AKI stage 3
Serum creatinine trajectory during ICU stay
- FA independently associated with creatinine trajectory over the whole observation period
Original publication
Influence of fluid accumulation on major adverse kidney events in critically ill patients – an observational cohort study. Ann Intensive Care. Published 8 April 2024. doi:10.
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