Association of fluid creep and maintenance fluids on major adverse kidney events in critically ill patients – An observational cohort study
Main finding · MAKE30Result — go to the resultAdjusted odds ratio 1.004 95% CI 1.001–1.008Authors' conclusion
In a large mixed ICU cohort, higher exposure to fluid creep/ maintenance fluids was consistently associated with MAKE30 and its components.
Study context
- Population
- Adult intensive care unit (ICU) patients, tertiary care center in Switzerland, January 2014–December 2017
- Participants
- 12,716 patients
- Exposure
- Fluid creep/maintenance fluid intake
- Outcome
- Major adverse kidney events (MAKE30)
- Follow-up
- 30 days
Methodological detailssingle-centre, multivariable logistic regression adjusted for typical confounders
- Single-centre
- Multivariable logistic regression adjusted for typical confounders
Main finding
MAKE30
Adjusted odds ratio
1.004
95% CI 1.001–1.008
P = 0.016
Each additional milliliter of fluid creep/maintenance fluids per kilogram body weight per day
aOR 1.004 (95% CI 1.001–1.008); P = 0.016
Each additional milliliter of fluid creep/maintenance fluids per, as printed
As reported in the abstract
- MAKE30 events, whole cohort
- 1812 (14%)
Observational data: associations, not effects.
Secondary outcomes
MAKE30 components: 30-day mortality, renal replacement therapy (RRT), persistent renal dysfunction
- Fluid creep/maintenance fluids associated with all components
Original publication
Association of fluid creep and maintenance fluids on major adverse kidney events in critically ill patients – An observational cohort study. J Crit Care. Published 24 May 2026. doi:10.
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