Cardiothoracic & vascular anesthesia
Nephrocheck for Prediction of In-Hospital Acute Kidney Injury and Major Adverse Kidney Events After Cardiac Surgery
Authors' conclusion
Nephrocheck AKI risk score 6 hours post-CPB was significantly associated with in-hospital postoperative AKI. Peak postoperative NephroCheck measurements were also significantly associated with MAKE up to 5 years after cardiac surgery.
Study context
- Population
- Patients undergoing nonemergent cardiac surgery with cardiopulmonary bypass (CPB)
- Participants
- 610 patients
- Comparison
- Postoperative Nephrocheck acute kidney injury (AKI) risk score (log2-transformed) and its association with AKI and major adverse kidney events (MAKE)
- Outcome
- In-hospital postoperative AKI (6-h post-CPB Nephrocheck score); MAKE up to 5 years (peak Nephrocheck score)
Performance
As reported in the abstract
In-hospital AKI
Odds ratio (95% CI)P value
Each twofold increase in the 6-hour biomarker concentrationunadjusted; adjusted OR range 1.39-1.42, P < .001
1.49(1.27–1.75)
P < 0.001ROC-derived threshold >0.14unadjusted; adjusted OR range 2.28-2.34, P < .001
2.43(1.60–3.69)
P < 0.001Each twofold increase in the 6-hour biomarker, as printed
- Incidence of postoperative all-stage in-hospital AKI
- 110/610 (18.0%)
Further findings
MAKE up to 5 years
| HR (95% CI) | P value | ||
|---|---|---|---|
| Quadratic term of peak NephroCheckUnadjusted; adjusted HR range 1.06-1.07, P < .008 | 1.09 (1.04–1.13) | P < 0.001 | |
| Peak Nephrocheck AKI risk score >1.69 unitsUnadjusted; adjusted HR range 1.75-2.04, P < .001 | 2.11 (1.55–2.85) | P < 0.001 | |
| 0.20.5125Hazard ratio (log scale) |
- MAKE up to 5 years — Incidence of MAKE
- 257/610 (42.1%)
MAKE up to 5 years
- Nonlinear association; linear and cubic terms not significant
Original publication
Nephrocheck for Prediction of In-Hospital Acute Kidney Injury and Major Adverse Kidney Events After Cardiac Surgery. Anesth Analg. Published 5 May 2026. doi:10.
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