Influence of gender on age-associated in-hospital mortality in patients with sepsis and septic shock: a prospective nationwide multicenter cohort study
Authors' conclusion
Gender may influence age-associated sepsis outcomes.
Study context
- Population
- Adults diagnosed with sepsis in the EDs of 19 South Korean hospitals, September 2019–December 2021
- Participants
- 6,442 adults · 19 hospitals
- Exposure
- Male vs female
- Malen = 3,650
- Outcome
- In-hospital mortality
Methodological detailsnationwide, multicentre, registry (Korean Sepsis Alliance)
- Nationwide
- Multicentre
- Registry (Korean Sepsis Alliance)
Main finding
As reported in the abstract
Male vs FemaleEstimate (95% CI)
In-hospital mortality
aOR 1.15(1.02–1.29)
Age 19-50
OR 0.57(0.35–0.93)
- Female: risk of death relatively stable until around age 80
- P for linearity = 0.77
- Male: linear increase in risk of in-hospital death until around age 80
- P for linearity < 0.01
Observational data: associations, not effects.
Further findings
Respiratory infection
P < 0.01
Urinary tract infection
P < 0.01
| Outcome | aOR (95% CI) | |
|---|---|---|
| In-hospital mortality, respiratory infection, age 19-50 (subgroup) | 0.29 (0.12–0.69) | |
| 0.10.31310Adjusted odds ratio (log scale) |
Original publication
Influence of gender on age-associated in-hospital mortality in patients with sepsis and septic shock: a prospective nationwide multicenter cohort study. Crit Care. Published 11 June 2023. doi:10.
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