Influence of underlying condition and performance of sepsis bundle in very old patients with sepsis: a nationwide cohort study
Authors' conclusion
Addressing underlying conditions and enhancing sepsis bundle adherence is crucial for better outcomes in very old patients with sepsis.
Study context
- Population
- Adults with sepsis aged ≥ 80 years, Korean Sepsis Alliance Database3,733 aged ≥ 80 years
- Participants
- 11,981 adults
- Exposure
- In-hospital survivors vs non-survivors among very old patients with sepsis
- Outcome
- In-hospital mortality and its association with underlying conditions and sepsis bundle compliance
Methodological detailsprospectively collected registry data
- Prospectively collected registry data
Main finding
As reported in the abstract
Factors associated with in-hospital mortality (aged ≥ 80 years)
In-hospital survivors
69.8%
Observational data: associations, not effects.
Further findings
Sepsis bundle performance (1-h, 3-h, 6-h)
- Survivors had lower lactate measurement but higher fluid therapy and vasopressor use within the 1-h bundle; similar trends in 3-h and 6-h bundles
- Survivors more likely to receive appropriate empiric antibiotics within 24 h
Original publication
Influence of underlying condition and performance of sepsis bundle in very old patients with sepsis: a nationwide cohort study. Ann Intensive Care. Published 4 December 2024. doi:10.
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