Respiratory failure & ventilation
Inhaled Δ9-tetrahydrocannabinol does not enhance oxycodone-induced respiratory depression: randomised controlled trial in healthy volunteers
Authors' conclusion
In humans, THC has no effect on ventilatory control after placebo or oxycodone pretreatment.
Study context
- Population
- Healthy volunteerscrossover
- Participants
- 18 volunteers
- Comparison
- Inhaled THC after placebo vs after oral oxycodone 20 mg pretreatment
- Primary endpoint
- Isohypercapnic ventilation at end-tidal Pco2 of 55 mm Hg or 7.3 kPa (VE55)
- Follow-up
- 1-h intervals for 7 h after placebo/oxycodone intake
Methodological detailscrossover
- Crossover
Primary result
As reported in the abstract
VE55 change with first cannabis inhalation
- Placebo: VE55 from 20.3 (3.1) to 23.8 (2.4) L min-1
- P=0.06
- Oxycodone: VE55 from 11.8 (2.8) to 13.0 (3.9) L min-1
- P=0.83
Further findings
VE55 with oxycodone vs placebo (before cannabis)
- Oxycodone decrease in VE55; placebo without effect
- 30%
Second cannabis inhalation · 4.5 h
- No effect on VE55
Safety
- Second cannabis inhalation slightly increased sedation
Original publication
Inhaled Δ9-tetrahydrocannabinol does not enhance oxycodone-induced respiratory depression: randomised controlled trial in healthy volunteers. Br J Anaesth. Published 31 January 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →