Cardiothoracic & vascular anesthesia
Intensity of one-lung ventilation and postoperative respiratory failure: A hospital registry study
Main finding · MP during OLV and PRFResult — go to the resultAdjusted odds ratio 1.22 95% CI 1.13–1.31Authors' conclusion
A higher intensity of OLV, mainly driven by driving pressure, is dose-dependently associated with PRF
Study context
- Population
- Adults undergoing GA with one-lung ventilation (OLV) for thoracic surgery, New England tertiary healthcare network, 2006–2020
- Participants
- 878 adults
- Exposure
- Higher vs lower mechanical power during OLV
- Postoperative respiratory failure (PRF)n = 106
- Outcome
- Postoperative respiratory failure (emergency NIV or reintubation within seven days)
- Follow-up
- 7 days
Methodological detailshospital registry, generalized propensity score weighted
- Hospital registry
- Generalized propensity score weighted
Main finding
MP during OLV and PRF
Adjusted odds ratio
1.22
95% CI 1.13–1.31
P < 0.001
By group
Higher MP during OLV
aOR 1.22 (95% CI 1.13–1.31); P < 0.001
Per 1 J/min increase, as printed
As reported in the abstract
- PRF incidence
- 106 (12.1%)
Observational data: associations, not effects.
Further findings
Dominance analysis of PRF predictors (contribution to Pseudo-R2)
- Driving pressure over respiratory rate and tidal volume
- 0.017
- Dynamic over static component of mechanical power (MP)
- 0.021
- MP during OLV over two-lung ventilation
- 0.036
Original publication
Intensity of one-lung ventilation and postoperative respiratory failure: A hospital registry study. Anaesth Crit Care Pain Med. Published 24 May 2023. doi:10.
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