Intermittent body composition analysis as monitoring tool for muscle wasting in critically ill COVID-19 patients
Authors' conclusion
Muscle wasting in critically ill COVID-19 patients is severe and correlates with survival.
Study context
- Population
- Critically ill COVID-19 patients with ≥3 clinically indicated computed tomography (CT) scans during hospitalization239 assessments
- Participants
- 54 patients
- Exposure
- Non-survivors vs survivors
- Outcome
- Psoas muscle area (PMA) loss per day and its association with survival
Methodological detailsintermittent CT-based body composition analysis, linear mixed model, Cox regression, ROC analysis
- Intermittent CT-based body composition analysis
- Linear mixed model
- Cox regression
- ROC analysis
Main finding
As reported in the abstract
Long-term PMA loss rate per day
P < 0.001
Observational data: associations, not effects.
Further findings
Maximum muscle decay per day
P = 0.039
First available decay rate
- Not significantly different between survival groups; significantly associated with survival in Cox regression
- P = 0.011
Discrimination for survival (ROC)
- PMA loss averaged over the stay, AUC (greatest discriminatory power)
- 0.777
- Threshold long-term PMA decline per day; loss beyond it a significant predictor of mortality
- 1.84%
Original publication
Intermittent body composition analysis as monitoring tool for muscle wasting in critically ill COVID-19 patients. Ann Intensive Care. Published 8 July 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →