Mechanistic Specificity of Capillary Leak Indices: Validation in Heart Failure as a Negative Control
Authors' conclusion
Clinical capillary leak indices do not accurately reflect true capillary permeability in a cohort of patients with chronic and acute-on-chronic heart failure
Study context
- Population
- Adults with chronic HF (stable outpatients and acute decompensation) undergoing clinically indicated blood volume analysis, tertiary-care academic medical center
- Outcome
- Correlation (Spearman) of clinical capillary leak indices (SOFA score, Capillary Leak Index, Vascular Leak Index, Hematocrit-Albumin Difference) with transcapillary escape rate of albumin (TERalb)
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Correlation of capillary leak indices with TERalb
- Indices showed weak or absent correlation with transcapillary escape rate of albumin (TERalb), indicating a lack of mechanistic specificity outside acute inflammatory illness
Observational data: associations, not effects.
Original publication
Mechanistic Specificity of Capillary Leak Indices: Validation in Heart Failure as a Negative Control. Crit Care Med. Published 12 August 2026. doi:10.
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