Acute skeletal muscle wasting in patients with acute kidney injury requiring continuous kidney replacement therapy: A prospective multicenter study
Authors' conclusion
Patients with AKI requiring CKRT experienced significant muscle wasting in the first week following CKRT initiation and had high rate of ICU-AW at hospital discharge.
Study context
- Population
- Critically ill adults with acute kidney injury (AKI) requiring continuous kidney replacement therapy (CKRT)
- Participants
- 23 adults
- Outcome
- Changes in rectus femoris muscle mass and quality on ultrasonography
- Follow-up
- First week after CKRT initiation
Methodological detailsmulticentre, two ultrasonography (US) academic hospitals
- Multicentre
- Two US academic hospitals
Main finding
As reported in the abstract
Rectus femoris muscle changes, Day 1 to Day 7 · Day 1 to Day 7
- Rectus femoris (RF) muscle thickness decrease, median [IQR]
- 10 % [3 %-20 %]
- RF cross-sectional area decrease, median [IQR]
- 19 % [12 %-22 %]
- Echo intensity increase (worse muscle quality), median [IQR]
- 14 % [5 %-25 %]
- Effect of time, cross-sectional area (CSA)
- F = 66.2, p < 0.001
- Effect of time, muscle thickness
- F = 27.1, p < 0.001
- Effect of time, echo intensity
- F = 22.5, p < 0.001
Observational data: associations, not effects.
Further findings
ICU-acquired weakness among survivors · hospital discharge
- Survivors meeting intensive care unit-associated weakness (ICU-AW) criteria
- 67 % (n = 10/15)
ICU death
- Died in ICU
- Six (26 %)
- Transitioned to comfort measures before study completion
- one (4 %)
Original publication
Acute skeletal muscle wasting in patients with acute kidney injury requiring continuous kidney replacement therapy: A prospective multicenter study. J Crit Care. Published 12 June 2025. doi:10.
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