Discontinuation of continuous kidney replacement therapy in patients with acute kidney injury: A pilot study
Authors' conclusion
A standardized approach did not improve the rate of successful CKRT discontinuation.
Study context
- Population
- ICU patients with acute kidney injury (AKI) requiring continuous kidney replacement therapy (CKRT), 7/2021–3/2024373 screened
- Participants
- 35 vs 32
- Exposure
- Standardized daily form guiding CKRT discontinuation vs standard care
- Interventionn = 35
- Standard caren = 32reference
- Outcome
- Successful CKRT discontinuation (free from kidney replacement therapy for seven consecutive days)
Main finding
As reported in the abstract
Successful discontinuation among survivors at day 7 after CKRT discontinuation · day 7 after CKRT discontinuation
Observational data: associations, not effects.
Further findings
| Outcome | Intervention |
|---|---|
| Prediction of successful discontinuation by cystatin C alone or with 2-h creatinine clearance · at CKRT discontinuation | |
| AUROC | 0.8 (95% CI, 0.57-0.99) |
Adherence to discontinuation guidance
- CKRT stopped when discontinuation encouraged
- 26/35 (74%)
- CKRT continued when discontinuation not encouraged
- 53/59 (90%)
Prediction of successful discontinuation by cystatin C alone or with 2-h creatinine clearance · at CKRT discontinuation
- Performance fair; best in the intervention cohort
Original publication
Discontinuation of continuous kidney replacement therapy in patients with acute kidney injury: A pilot study. J Crit Care. Published 3 March 2026. doi:10.
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