International Consensus Criteria for Pediatric Sepsis and Septic Shock

Sepsis in children identified by a Phoenix Sepsis Score ≥2 points in children with suspected infection (potentially life-threatening dysfunction of respiratory, cardiovascular, coagulation and/or neurological systems); in-hospital mortality 7.1% in higher-resource and 28.5% in lower-resource settings, >8 times that of children with suspected infection not meeting criteria

Septic shock defined as sepsis with cardiovascular dysfunction: ≥1 cardiovascular point in the Phoenix Sepsis Score (severe hypotension for age, blood lactate >5 mmol/L, or need for vasoactive medication); in-hospital mortality 10.8% and 33.5% in higher- and lower-resource settings

Systemic inflammatory response syndrome (SIRS)-based criteria (poor predictive properties) and the redundant term severe sepsis replaced