Intra-arterial lidocaine improves long-term survival in patients with hepatocellular carcinoma undergoing transcatheter arterial chemoembolisation: a retrospective propensity score-matched study
Authors' conclusion
Intra-arterial lidocaine might improve long-term survival in patients with HCC undergoing TACE and in the subgroup of patients receiving platinum.
Study context
- Population
- Patients with hepatocellular carcinoma (HCC) receiving transcatheter arterial chemoembolisation (TACE) as initial treatment, August 2011 to October 2016
- Participants
- 374 eligible patients
- Exposure
- Intra-arterial lidocaine vs no lidocaine during TACE
- Lidocainen = 96
- No lidocainen = 278reference
- Outcome
- PFS and overall survival
Methodological detailspropensity-score matched
- Propensity-score matched
Main finding
As reported in the abstract
- Lidocaine vs No lidocaine: P = 0.004
- Lidocaine vs No lidocaine: P < 0.001
- Lidocaine vs No lidocaine: P < 0.001
- Lidocaine vs No lidocaine: P = 0.001
- Propensity score matching
Observational data: associations, not effects.
Further findings
| Outcome | P value |
|---|---|
| Independent prognostic factor (multivariate analysis)Lidocaine vs No lidocaine | P = 0.011 |
| Independent prognostic factor (multivariate analysis)Lidocaine vs No lidocaine | P = 0.044 |
| PFS and overall survival (subgroup: TACE regimen with platinum)Lidocaine vs No lidocaine | P = 0.014 |
| PFS and overall survival (subgroup: TACE regimen with platinum)Lidocaine vs No lidocaine | P = 0.023 |
Independent prognostic factor (multivariate analysis)
- Intra-arterial lidocaine an independent prognostic factor for progression-free survival (PFS) and overall survival
PFS and overall survival (subgroup: TACE regimen with platinum)
- Impact of lidocaine similar in patients receiving platinum
Original publication
Intra-arterial lidocaine improves long-term survival in patients with hepatocellular carcinoma undergoing transcatheter arterial chemoembolisation: a retrospective propensity score-matched study. Br J Anaesth. Published 20 March 2025. doi:10.
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