Intraoperative Electroencephalography Alpha-Band Power Is a Better Proxy for Preoperative Low Montreal Cognitive Assessment (MoCA) Under Propofol Compared With Sevoflurane
Authors' conclusion
We suggest that intraoperative EEG biomarkers of abnormal cognition differ between propofol and sevoflurane under general anesthesia.
Study context
- Population
- Patients under GA with intraoperative EEG monitoring and preoperative MoCA assessment 1 day before intervention
- Participants
- 106 participants
- Exposure
- Propofol vs Sevoflurane
- Propofoln = 55
- Sevofluranen = 51reference
- Outcome
- Difference in α-BP between low and normal MoCA patients
Methodological detailsmonocentric, adjusted for age and drug dosage, depth of anesthesia (DoA) assessed by SEF95, maintained within (8-13) Hz
- Monocentric
- Adjusted for age and drug dosage
- DoA assessed by SEF95, maintained within (8-13) Hz
Main finding
As reported in the abstract
P = 0.022
Observational data: associations, not effects.
Further findings
| Outcome | OR (CI) | P value | |
|---|---|---|---|
| Low α-BP and low MoCA, propofol (adjusted for age and dose)Not significant under sevoflurane | 0.39 (0.16–0.94) | P = 0.034 | |
| 0.10.31310Odds ratio (log scale) |
Theta-band power and low MoCA, sevoflurane (adjusted for age and dose)
| OR (CI) | P value | ||
|---|---|---|---|
| Sevoflurane | 0.31 (0.13–0.73) | P = 0.007 | |
| 0.10.31310Odds ratio (log scale) |
SEF95 and age
- Not statistically different between sevoflurane and propofol groups
Original publication
Intraoperative Electroencephalography Alpha-Band Power Is a Better Proxy for Preoperative Low MoCA Under Propofol Compared With Sevoflurane. Anesth Analg. Published 4 April 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →