Pediatric anesthesia & critical care
Intraoperative fluid administration volumes during pediatric liver transplantation and postoperative outcomes: A multicenter analysis
Authors' conclusion
The amount of intraoperative fluid administration is correlated with duration of postoperative mechanical ventilation in children undergoing liver transplantation, however, it does not seem to be a strong factor.
Study context
- Population
- Children undergoing liver transplantation at three major pediatric liver transplant centers
- Participants
- 286 successful liver transplants
- Exposure
- Intraoperative fluid volume vs postoperative outcomes
- Outcome
- Duration of postoperative mechanical ventilation
Methodological detailsmulticentre, 3 centres
- Multicentre
- 3 centres
Main finding
As reported in the abstract
- Median duration of postoperative mechanical ventilation, h (IQR 0.0, 35.4)
- 10.8
- Univariate linear regression, intraoperative fluids vs ventilation duration: weak correlation, r2 (p = .001)
- r2 = .037
- Stepwise linear regression, intraoperative fluids remained weakly correlated with ventilation duration, r2 (p = .04)
- r2 = .161
- Center (Riley Children's Health vs Children's Health Dallas) independently correlated with ventilation duration
- p = .001
- Open abdominal incision after transplant independently correlated with ventilation duration
- p = .001
Observational data: associations, not effects.
Secondary outcomes
ICU LOS
- Median ICU LOS, days (IQR 2.7, 6.8)
- 4.3
Hospital LOS
- Median hospital LOS, days (9.8, 21.1)
- 13.6
Original publication
Intraoperative fluid administration volumes during pediatric liver transplantation and postoperative outcomes: A multicenter analysis. Paediatr Anaesth. Published 16 June 2023. doi:10.
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