Perioperative medicine & outcomes
Intraoperative hypotension and postoperative outcomes: a meta-analysis of randomised trials
Pooled result · Nine studiesResult — go to the resultOdds ratio 0.88 95% CI 0.65–1.18Authors' conclusion
Pooled randomised evidence shows that a target intraoperative mean arterial pressure ≤60 mm Hg is not associated with increased mortality; nevertheless it is surprisingly associated with a reduced rate of atrial fibrillation and of length of hospital stay.
Study context
- Population
- Surgical patients in randomised trials of intraoperative BP management
- Participants
- 9,359 patients · 10 RCTs
- Comparison
- Permissive vs targeted intraoperative BP management
- Outcome
- All-cause mortality
- Follow-up
- Longest available
Methodological detailsSearched PubMed, Cochrane, and Embase up to June 2023
- Searched PubMed, Cochrane, and Embase up to June 2023
Pooled result
Nine studies
Odds ratio
0.88
95% CI 0.65–1.18
P = 0.38
Events by group
Permissive vs Targeted
OR 0.88 (95% CI 0.65–1.18); P = 0.38
As reported in the abstract
Further pooled results
| Outcome | Permissive | Targeted | OR (95% CI) | P value | |
|---|---|---|---|---|---|
| AFI2=0% | 2.6% | 3.3% | 0.71 (0.53–0.96) | P = 0.03 | |
| 0.512Odds ratio (log scale) |
| Outcome | Mean difference (days) (95% CI) | P value | |
|---|---|---|---|
| Hospital LOSI2=0% | −0.20 (−0.26 to −0.13) | P < 0.001 | |
| −0.4−0.200.2Difference, days (linear scale) |
Cardiac and noncardiac surgery (subgroup)
- No significant differences in subgroup analysis
Original publication
Intraoperative hypotension and postoperative outcomes: a meta-analysis of randomised trials. Br J Anaesth. Published 20 September 2023. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →