Cardiothoracic & vascular anesthesia
Intraoperative Methadone in Adult Cardiac Surgical Patients and Risks for Postoperative QTc Prolongation
Authors' conclusion
A single intraoperative intravenous methadone dose did not prolong the QTc significantly or increase the incidence of arrhythmias and may be safe in adult cardiac surgical patients.
Study context
- Population
- Adults undergoing elective cardiac surgery at a tertiary academic institution, July 2020–July 2023
- Participants
- 1,040 adults
- Exposure
- Methadone vs Nonmethadone
- Methadonen = 423
- Nonmethadonen = 617reference
- Outcome
- Change in QTc and percent QTc change between preoperative QTc and postoperative QTc
- Follow-up
- ICU admission
Methodological detailssingle-centre
- Single-centre
Main finding
As reported in the abstract
Change and percent change in QTc
- No significant differences in baseline QTc, immediate postoperative QTc, changes in QTc, or percent change in QTc between Methadone and Nonmethadone
- QTc prolonged immediately postoperatively and normalized 24 hours after surgery in both groups
Observational data: associations, not effects.
Secondary outcomes
30-day mortality, 1-year mortality, days to death
- No significant differences
Safety
Ventricular or atrial arrhythmias
- No significant differences
Original publication
Intraoperative Methadone in Adult Cardiac Surgical Patients and Risks for Postoperative QTc Prolongation. J Cardiothorac Vasc Anesth. Published 16 November 2024. doi:10.
Composed by AI from the published abstract and checked against it. How Briefs are made →