Cardiothoracic & vascular anesthesia
Intravenous iron administration before cardiac surgery reduces red blood cell transfusion in patients without anaemia
Authors' conclusion
In patients without anaemia undergoing on-pump cardiac surgery, treatment with a single dose of 1000 mg ferric carboxymaltose i.v. 1-3 days before surgery significantly reduced the need for red cell transfusions and increased the postoperative haemoglobin concentration.
Study context
- Population
- Patients without anaemia undergoing on-pump cardiac surgery
- Participants
- 200 patients
- Comparison
- Single i.v. ferric carboxymaltose vs placebo 24-72 h before surgery
- Ferric carboxymaltosen = 102
- Placebon = 98reference
- Primary endpoint
- Number of red cell units transfused
- Follow-up
- First four postoperative days
Methodological detailsdouble-blind, placebo-controlled, Conducted October 2016 to November 2019; follow-up up to 6 weeks after surgery
- Double-blind
- Placebo-controlled
- Conducted October 2016 to November 2019; follow-up up to 6 weeks after surgery
Primary result
As reported in the abstract
P = 0.007
Secondary outcomes
Blood haemoglobin concentration · Postoperative Day 4
P = 0.03
| Outcome | P value |
|---|---|
| Blood haemoglobin concentration · up to 6 weeks after surgery | P = 0.012 |
Parts of this Brief are withheld: the automatic checks could not confirm them against the abstract.
Original publication
Intravenous iron administration before cardiac surgery reduces red blood cell transfusion in patients without anaemia. Br J Anaesth. Published 12 October 2023. doi:10.
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